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Product Details
13789-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RAP2A Fusion Protein Ag4808 (1-183 aa encoded by BC041333)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MREYKVVVL GSGGVGKSAL TVQFVTGTFI EKYDPTIEDF YRKEIEVDSS PSVLEILDTA GTEQFASMRD LYIKNGQGFI LVYSLVNQQS FQDIKPMRDQ IIRVKRYEKV PVILVGNKVD LESEREVSSS EGRALAEEWG CPFMETSAKS KTMVDELFAE IVRQMNYAAQ PDKDDPCCSA CNIQ (1-183 aa encoded by BC041333)
Target Information
RAP2A is a small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RAP2, member of RAS oncogene family (K-rev); Ras-related protein Rap-2a; RbBP-30; RP11-128N14.2
Gene Aliases: 5830461H18Rik; K-REV; KREV; RAP2; RAP2A; RbBP-30
UniProt ID: (Human) P10114, (Mouse) Q80ZJ1
Entrez Gene ID: (Human) 5911, (Mouse) 76108
positive regulation of protein phosphorylation
microvillus assembly
negative regulation of cell migration
actin cytoskeleton reorganization
positive regulation of protein autophosphorylation
Rap protein signal transduction
cellular protein localization
cellular response to drug
establishment of protein localization
establishment of epithelial cell apical/basal polarity
regulation of JNK cascade
regulation of dendrite morphogenesis
protein localization to plasma membrane
signal transduction
small GTPase mediated signal transduction
metabolic process
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