PA5-28905 targets RAP2A in IF and WB applications and shows reactivity with Human samples.
The PA5-28905 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 183 of Human RAP2A.
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Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
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Protein Aliases: K-REV; KREV; member of RAS oncogene family (K-rev); RAP2; RAP2, member of RAS oncogene family (K-rev); Ras-related protein Rap-2a; RbBP-30
Gene Aliases: K-REV; KREV; RAP2; RAP2A; RbBP-30
UniProt ID: (Human) P10114
Entrez Gene ID: (Human) 5911