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Invitrogen
RAP2A Polyclonal Antibody
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Product Details
PA5-28905
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human RAP2A Recombinant protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Mouse (99%), Xenopus laevis (98%), Sheep (98%), Rhesus Monkey (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RAP2A is a small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: pRb interacting protein; RAP2, member of RAS oncogene family (K-rev); Ras-related protein Rap-2a; RbBP-30; RP11-128N14.2; small GTP binding protein; unnamed protein product
Gene Aliases: K-REV; KREV; RAP2; RAP2A; RbBP-30
UniProt ID: (Human) P10114
Entrez Gene ID: (Human) 5911
signal transduction
protein localization
actin cytoskeleton organization
positive regulation of cell migration
negative regulation of cell migration
Rap protein signal transduction
establishment of protein localization
regulation of JNK cascade
regulation of dendrite morphogenesis
regulation of synapse assembly
regulation of postsynaptic membrane neurotransmitter receptor levels
positive regulation of microvillus assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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