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Invitrogen
RAPGEF4 Polyclonal Antibody
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Product Details
PA5-72746
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EPAC2 antibody for a 15 amino acid synthetic peptide near the amino terminus of human EPAC2. The immunogen is within the first 50 amino acids of EPAC2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP-dependent Rap1 guanine-nucleotide exchange factor; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; cAMP-regulated guanine nucleotide exchange factor IIB; EPAC 2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; gefii; putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; RAP guanine-nucleotide-exchange factor (GEF) 4; unnamed protein product
Gene Aliases: 1300003D15Rik; 5730402K07Rik; 6330581N18Rik; CAMP-GEFII; CAMPS; CGEF2; EPAC; EPAC 2; Epac-2; EPAC2; mKIAA4040; Nbla00496; RAPGEF4
UniProt ID: (Human) Q8WZA2, (Mouse) Q9EQZ6
Entrez Gene ID: (Human) 11069, (Rat) 252857, (Mouse) 56508
nucleotide binding
guanyl-nucleotide exchange factor activity
protein binding
cAMP binding
protein binding, bridging
small GTPase binding
Ras guanyl-nucleotide exchange factor activity
cAMP-dependent protein kinase regulator activity
Ras GTPase binding
protein complex binding
guanyl-nucleotide exchange factor
adaptive immune response
exocytosis
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
small GTPase mediated signal transduction
Ras protein signal transduction
calcium ion regulated exocytosis
regulation of exocytosis
insulin secretion
positive regulation of insulin secretion
intracellular signal transduction
hormone secretion
regulation of insulin secretion
regulation of synaptic vesicle cycle
signal transduction
heart development
positive regulation of smooth muscle cell migration
cAMP-mediated signaling
positive regulation of GTPase activity
regulation of protein kinase activity
regulation of dendrite development
negative regulation of synaptic transmission
regulation of protein phosphorylation
positive regulation of action potential
positive regulation of protein secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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