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Product Details
12556-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RAPGEF5 Fusion Protein Ag3229 (129-444 aa encoded by BC039203)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KKYQGKEEN SDVPRRKRKV LHLVSQWIAL YKDWLPEDEH SKMFLKTIYR NVLDDVYEYP ILEKELKEFQ KILGMHRRHT VDEYSPQKKN KALFHQFSLK ENWLQHRGTV TETEEIFCHV YITEHSYVSV KAKVSSIAQE ILLCSQLGKR VQLVKKFIKI AAHCKAQRNL NSFFAIVMGL NTASVSRLSQ TWEKIPGKFK KLFSELESLT DPSLNHKAYR DAFKKMKPPK IPFVPLLLKD VTFIHEGNKT FLDNLVNFEK LHMIADTVRT LRHCRTNQFG DLSPKEHQEL KSYVNHLYVI DSQQALFELS HRIEPRV (129-444 aa encoded by BC039203 )
Target Information
Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation. Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein that is expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse and rat. The gene that encodes Repac maps to human chromosome 7p15.3, with high expression of this region linking to positive response to erlotinib therapy for those with non-small-cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Guanine nucleotide exchange factor for Rap1; M-Ras-regulated GEF; M-Ras-regulated Rap GEF; MR-GEF; Mras regulated guanine nucleotide exchange factor; Rap guanine nucleotide exchange factor (GEF) 5; Rap guanine nucleotide exchange factor 5; Related to Epac; Repac; tcag7.1034
Gene Aliases: 4932413M22; C86120; D030051B22Rik; GFR; KIAA0277; mKIAA0277; mmr-gef; MR-GEF; MRGEF; RAPGEF5; REPAC
UniProt ID: (Human) Q92565, (Mouse) Q8C0Q9
Entrez Gene ID: (Human) 9771, (Mouse) 217944
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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