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Invitrogen
RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)
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FIGURE: 1 / 3
RARA/RARB/RARG Antibody (MA570053) in WB
Western blot analysis of RARA/RARB/RARG in various lysates. Samples were incubated with RARA/RARB/RARG monoclonal antibody (Product # MA570053) using a dilution of 1:1,000 in 5% NFDM/TBST at 4°C overnight followed by Goat Anti-Rabbit IgG - HRP Secondary Antibody at a dilution of 1:50,000 for 1 hour at room temperature. Lane 1: SK-Br-3 cell lysate; Lane 2: T-47D cell lysate; Lane 3: A375 cell lysate; Lane 4: HeLa cell lysate. Lysates/proteins at 20 µg/Lane. Predicted band size: 50 kDa; Observed band size: 58 kDa. Exposure time: 3 minutes; E... View More
Product Details
MA570053
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH08-74
Immunogen
Recombinant protein within human RARG aa 155-454.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: SK-Br-3 cell lysate, T-47D cell lysate, A375 cell lysate, HeLa cell lysate.
Subcellular location: Nucleus, Cytoplasm.
Target Information
All three genes are part of the nuclear receptor family and are crucial in regulating cell growth, differentiation, and apoptosis. They share structural similarities, including a DNA-binding domain and a ligand-binding domain, allowing them to bind to specific DNA sequences and regulate target gene expression. RARA (Retinoic Acid Receptor Alpha) is a nuclear receptor that mediates the effects of retinoic acid (a metabolite of vitamin A) by regulating gene transcription. It is located on chromosome 17q21.2. RARB (Retinoic Acid Receptor Beta) also functions as a nuclear receptor for retinoic acid and is involved in gene activation. It is located on chromosome 3p24. RARG (Retinoic Acid Receptor Gamma) plays a similar role in mediating retinoic acid effects and is found on chromosome 12q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; Nuclear receptor subfamily 1 group B member 3; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR-alpha; RAR-beta; RAR-epsilon; RAR-gamma; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor alpha; Retinoic acid receptor beta; Retinoic acid receptor gamma; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide; retinoic acid receptor, gamma
Gene Aliases: HAP; MCOPS12; NR1B1; NR1B2; NR1B3; RAR; RARA; RARB; RARbeta1; RARC; RARG; RRB2
UniProt ID: (Human) P10276, (Human) P10826, (Human) P13631
Entrez Gene ID: (Human) 5914, (Human) 5915, (Human) 5916
translation repressor activity, nucleic acid binding
RNA polymerase II regulatory region sequence-specific DNA binding
retinoic acid binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
transcription coactivator activity
transcription corepressor activity
receptor binding
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
histone deacetylase binding
protein kinase B binding
retinoic acid-responsive element binding
protein heterodimerization activity
mRNA 5'-UTR binding
protein kinase A binding
alpha-actinin binding
DNA binding
protein complex binding
retinoid X receptor binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
neural tube closure
liver development
glandular epithelial cell development
outflow tract septum morphogenesis
growth plate cartilage development
transcription initiation from RNA polymerase II promoter
protein phosphorylation
signal transduction
germ cell development
spermatogenesis
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
hippocampus development
prostate gland development
negative regulation of granulocyte differentiation
embryonic camera-type eye development
regulation of myelination
response to estradiol
response to retinoic acid
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
positive regulation of interleukin-5 production
response to vitamin A
response to cytokine
multicellular organism growth
negative regulation of apoptotic process
apoptotic cell clearance
steroid hormone mediated signaling pathway
response to ethanol
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
regulation of synaptic plasticity
retinoic acid receptor signaling pathway
positive regulation of binding
ventricular cardiac muscle cell differentiation
Sertoli cell fate commitment
limb development
face development
trachea cartilage development
chondroblast differentiation
negative regulation of cartilage development
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to estrogen stimulus
retinal pigment epithelium development
striatum development
negative regulation of chondrocyte differentiation
embryonic hindlimb morphogenesis
positive regulation of apoptotic process
embryonic eye morphogenesis
embryonic digestive tract development
growth plate cartilage chondrocyte growth
regulation of cell size
anterior/posterior pattern specification
positive regulation of programmed cell death
regulation of myeloid cell differentiation
canonical Wnt signaling pathway
prostate gland epithelium morphogenesis
Harderian gland development
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