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Invitrogen

RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)

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RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)

Product Details

MA570053

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH08-74

Immunogen

Recombinant protein within human RARG aa 155-454.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: SK-Br-3 cell lysate, T-47D cell lysate, A375 cell lysate, HeLa cell lysate.

Subcellular location: Nucleus, Cytoplasm.

Target Information

All three genes are part of the nuclear receptor family and are crucial in regulating cell growth, differentiation, and apoptosis. They share structural similarities, including a DNA-binding domain and a ligand-binding domain, allowing them to bind to specific DNA sequences and regulate target gene expression. RARA (Retinoic Acid Receptor Alpha) is a nuclear receptor that mediates the effects of retinoic acid (a metabolite of vitamin A) by regulating gene transcription. It is located on chromosome 17q21.2. RARB (Retinoic Acid Receptor Beta) also functions as a nuclear receptor for retinoic acid and is involved in gene activation. It is located on chromosome 3p24. RARG (Retinoic Acid Receptor Gamma) plays a similar role in mediating retinoic acid effects and is found on chromosome 12q13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; Nuclear receptor subfamily 1 group B member 3; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR-alpha; RAR-beta; RAR-epsilon; RAR-gamma; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor alpha; Retinoic acid receptor beta; Retinoic acid receptor gamma; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide; retinoic acid receptor, gamma

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Gene Aliases: HAP; MCOPS12; NR1B1; NR1B2; NR1B3; RAR; RARA; RARB; RARbeta1; RARC; RARG; RRB2

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UniProt ID: (Human) P10276, (Human) P10826, (Human) P13631

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Entrez Gene ID: (Human) 5914, (Human) 5915, (Human) 5916

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Function(s)
translation repressor activity, nucleic acid binding RNA polymerase II regulatory region sequence-specific DNA binding retinoic acid binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity transcription corepressor activity receptor binding protein binding transcription factor binding drug binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding retinoic acid-responsive element binding protein heterodimerization activity mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding DNA binding protein complex binding retinoid X receptor binding C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development neural tube closure liver development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development transcription initiation from RNA polymerase II promoter protein phosphorylation signal transduction germ cell development spermatogenesis female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation hippocampus development prostate gland development negative regulation of granulocyte differentiation embryonic camera-type eye development regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine multicellular organism growth negative regulation of apoptotic process apoptotic cell clearance steroid hormone mediated signaling pathway response to ethanol positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of translational initiation regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding ventricular cardiac muscle cell differentiation Sertoli cell fate commitment limb development face development trachea cartilage development chondroblast differentiation negative regulation of cartilage development cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus retinal pigment epithelium development striatum development negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis positive regulation of apoptotic process embryonic eye morphogenesis embryonic digestive tract development growth plate cartilage chondrocyte growth regulation of cell size anterior/posterior pattern specification positive regulation of programmed cell death regulation of myeloid cell differentiation canonical Wnt signaling pathway prostate gland epithelium morphogenesis Harderian gland development
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