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RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)

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RARA/RARB/RARG Recombinant Rabbit Monoclonal Antibody (PSH08-74)

Product Details

MA570053

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PSH08-74

Immunogen

Recombinant protein within human RARG aa 155-454.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: SK-Br-3 cell lysate, T-47D cell lysate, A375 cell lysate, HeLa cell lysate.

Subcellular location: Nucleus, Cytoplasm.

Target Information

All three genes are part of the nuclear receptor family and are crucial in regulating cell growth, differentiation, and apoptosis. They share structural similarities, including a DNA-binding domain and a ligand-binding domain, allowing them to bind to specific DNA sequences and regulate target gene expression. RARA (Retinoic Acid Receptor Alpha) is a nuclear receptor that mediates the effects of retinoic acid (a metabolite of vitamin A) by regulating gene transcription. It is located on chromosome 17q21.2. RARB (Retinoic Acid Receptor Beta) also functions as a nuclear receptor for retinoic acid and is involved in gene activation. It is located on chromosome 3p24. RARG (Retinoic Acid Receptor Gamma) plays a similar role in mediating retinoic acid effects and is found on chromosome 12q13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; nuclear receptor; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; Nuclear receptor subfamily 1 group B member 3; nuclear receptor; RAR beta; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; open reading frame 1; putative; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR beta 1'; RAR-alpha; RAR-beta; RAR-epsilon; RAR-gamma; RARA; RARB; RARbeta isoform 5; Retinoic acid receptor alpha; Retinoic acid receptor beta; Retinoic acid receptor gamma; retinoic acid receptor gamma 2; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product

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Gene Aliases: HAP; MCOPS12; NR1B1; NR1B2; NR1B3; RAR; RARA; RARalpha; RARB; RARbeta; RARbeta1; RARC; RARG; RARgamma; RRB2

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UniProt ID: (Human) P10276, (Human) P10826, (Human) P13631

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Entrez Gene ID: (Human) 5914, (Human) 5915, (Human) 5916

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Function(s)
translation repressor activity, nucleic acid binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription coactivator binding retinoic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding sequence-specific DNA binding retinoic acid-responsive element binding metal ion binding mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding heterocyclic compound binding sequence-specific double-stranded DNA binding macromolecular complex binding retinoid X receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development neural tube closure liver development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development regulation of transcription, DNA-templated protein phosphorylation germ cell development spermatogenesis female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation male gonad development positive regulation of gene expression negative regulation of gene expression negative regulation of translation hippocampus development cell differentiation prostate gland development regulation of granulocyte differentiation negative regulation of granulocyte differentiation embryonic camera-type eye development regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine multicellular organism growth mRNA transcription from RNA polymerase II promoter regulation of apoptotic process negative regulation of apoptotic process apoptotic cell clearance response to ethanol negative regulation of cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding ventricular cardiac muscle cell differentiation Sertoli cell fate commitment limb development face development bone development trachea cartilage development chondroblast differentiation negative regulation of cartilage development cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process regulation of hematopoietic progenitor cell differentiation negative regulation of pri-miRNA transcription from RNA polymerase II promoter chondrocyte development growth plate cartilage chondrocyte growth apoptotic process cell proliferation regulation of cell size anterior/posterior pattern specification regulation of gene expression programmed cell death negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis positive regulation of apoptotic process positive regulation of programmed cell death regulation of myeloid cell differentiation embryonic eye morphogenesis reproductive structure development gland development canonical Wnt signaling pathway bone morphogenesis epithelium development prostate gland epithelium morphogenesis Harderian gland development stem cell proliferation cellular response to leukemia inhibitory factor negative regulation of stem cell proliferation signal transduction striatum development neurogenesis embryonic digestive tract development neural precursor cell proliferation
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