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Invitrogen
RARB Polyclonal Antibody
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Product Details
PA5-33016
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bat,
Horse,
Human,
Non-human primate,
Pig
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 13 amino acid peptide from C-terminus of human RARB.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Horse, Pig, Opossum (100%); Dog, Turkey, Chicken (92%); Mouse, Panda (85%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; nuclear receptor; RAR beta; open reading frame 1; putative; RAR beta; RAR beta 1'; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; RARB; RARbeta isoform 5; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide; unnamed protein product
Gene Aliases: HAP; MCOPS12; NR1B2; RARB; RARbeta; RARbeta1; RRB2
UniProt ID: (Human) P10826
Entrez Gene ID: (Horse) 100051546, (Pig) 396710, (Human) 5915
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
macromolecular complex binding
metal ion binding
retinoid X receptor binding
heterocyclic compound binding
sequence-specific double-stranded DNA binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
glandular epithelial cell development
outflow tract septum morphogenesis
growth plate cartilage development
regulation of transcription, DNA-templated
apoptotic process
signal transduction
cell proliferation
programmed cell death
striatum development
neurogenesis
cell differentiation
regulation of myelination
negative regulation of chondrocyte differentiation
embryonic hindlimb morphogenesis
multicellular organism growth
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transcription from RNA polymerase II promoter
embryonic eye morphogenesis
retinoic acid receptor signaling pathway
embryonic digestive tract development
ventricular cardiac muscle cell differentiation
bone development
negative regulation of cartilage development
neural precursor cell proliferation
stem cell proliferation
negative regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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