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Proteintech
RARG Polyclonal Antibody
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Product Details
11424-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RARG Fusion Protein Ag1991 (1-300 aa encoded by BC019098)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATNKERLF AAGALGPGSG YPGAGFPFAF PGALRGSPPF EMLSPSFRGL GQPDLPKEMA SLSVETQSTS SEEMVPSSPS PPPPPRVYKP CFVCNDKSSG YHYGVSSCEG CKGFFRRSIQ KNMVYTCHRD KNCIINKVTR NRCQYCRLQK CFEVGMSKEA VRNDRNKKKK EVKEEGSPDS YELSPQLEEL ITKVSKAHQE TFPSLCQLGK YTTNSSADHR VQLDLGLWDK FSELATKCII KIVEFAKRLP GFTGLSIADQ ITLLKAACLD ILMLRICTRY TPEQDTMTFS DGLTLNRTQM H (1-300 aa encoded by BC019098)
Target Information
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma. Two main isoforms of RAR gamma exist: RAR gamma-1 has been found to be predominantly expressed in skin, while RAR gamma-2 has been found early in embryogenesis and in embryonal carcinoma cells. RAR gamma is also known as RARD. The corresponding gene for the retinoic acid receptor gamma 1 is NR1B3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nuclear receptor subfamily 1 group B member 3; RAR gamma 2; RAR Gamma-1; RAR-gamma; retinoic acid; retinoic acid receptor; Retinoic acid receptor gamma; retinoic acid receptor gamma 2; retinoic acid receptor gamma 4; unnamed protein product
Gene Aliases: NR1B3; RAR-gamma; RARC; RARD; RARG; RARgamma; RARgamma2
UniProt ID: (Human) P13631, (Mouse) P18911
Entrez Gene ID: (Human) 5916, (Mouse) 19411, (Rat) 685072
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
retinoid X receptor binding
sequence-specific double-stranded DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
chondrocyte development
glandular epithelial cell development
growth plate cartilage development
growth plate cartilage chondrocyte growth
regulation of transcription, DNA-templated
apoptotic process
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell size
anterior/posterior pattern specification
regulation of gene expression
positive regulation of gene expression
programmed cell death
cell differentiation
embryonic camera-type eye development
regulation of myelination
negative regulation of chondrocyte differentiation
response to retinoic acid
embryonic hindlimb morphogenesis
multicellular organism growth
positive regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cell differentiation
regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic eye morphogenesis
retinoic acid receptor signaling pathway
reproductive structure development
gland development
canonical Wnt signaling pathway
limb development
face development
bone development
bone morphogenesis
epithelium development
trachea cartilage development
prostate gland epithelium morphogenesis
negative regulation of cartilage development
Harderian gland development
cellular response to retinoic acid
stem cell proliferation
cellular response to leukemia inhibitory factor
negative regulation of stem cell proliferation
retinal pigment epithelium development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
camera-type eye development
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
retina development in camera-type eye
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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