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Product Details
27835-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RASA2/3 Fusion Protein Ag27152 (563-834 aa encoded by BC038456)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSGRRDPKS VEQPIVLKEG FMIKRAQGRK RFGMKNFKKR WFRLTNHEFT YHKSKGDQPL YSIPIENILA VEKLEEESFK MKNMFQVIQP ERALYIQANN CVEAKDWIDI LTKVSQCNQK RLTVYHPSAY LSGHWLCCRA PSDSAPGCSP CTGGLPANIQ LDIDGDRETE RIYSLFNLYM SKLEKMQEAC GSKSVYDGPE QEEYSTFVID DPQETYKTLK QVIAGVGALE QEHAQYKRDK FKKTKYGSQE HPIGDKSFQN YIRQQSETST HSI (563-834 aa encoded by BC038456)
Target Information
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1, 3, 4, 5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GAP1(IP4BP); GAP1m; GapIII; GAPIII activator 3; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; GTPase-activating protein 1m; GTPase-activating protein of RAS; Ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; R-Ras gap; R-ras RTPase activating protein-3; Ras GTPase-activating protein 2; Ras GTPase-activating protein 3; Ras GTPase-activating protein III
Gene Aliases: 5430433H21Rik; AA517451; AI326412; AU023900; C86362; E130011G04; GAP1IP4BP; GAP1M; GAPIII; RASA2; RASA3; RASGAP; scat
UniProt ID: (Human) Q15283, (Human) Q14644, (Mouse) P58069, (Mouse) Q60790
Entrez Gene ID: (Human) 5922, (Human) 22821, (Mouse) 114713, (Mouse) 19414
MAPK cascade
signal transduction
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
release of sequestered calcium ion into cytosol
intracellular signal transduction
regulation of GTPase activity
cellular response to heat
calcium ion transmembrane transport
Performance Guarantee
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