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Invitrogen
RASA4 Polyclonal Antibody
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FIGURE: 1 / 1
RASA4 Antibody (PA5-110274) in WB
Western blot analysis of RASA4 in extracts of various cell lines. Samples were incubated with RASA4 Polyclonal antibody (Product # PA5-110274) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-110274
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human RASA4 (NP_008920.5).
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Amount
74 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HLPPTFHAVA FYVMDEDALS RDDVIGKVCL TRDTIASHPK GFSGWAHLTE VDPDEEVQGE IHLRLEVWPG ARACRLRCSV LEARDLAPKD RNGTSDPFVR VRYKGRTRET SIVKKSCYPR WNETFEFELQ EGAMEALCVE AWDWDLVSRN DFLGKVVIDV QRLRVVQQEE GWFRLQPDQS KSRRHDEGNL GSLQLEVRLR DETVLPSSYY QPLVHLLCHE VKLGMQGPGQ L
Target Information
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca2+-promoted Ras inactivator; Ca2+promoted Ras inactivator; Calcium-promoted Ras inactivator; Ras GTPase-activating protein 4; RAS p21 protein activator 4; RasGAP-activating-like protein 2; unnamed protein product
Gene Aliases: AA793972; AW112107; BB079060; CAPRI; GAPL; KIAA0538; RASA4; RGD1565457
UniProt ID: (Human) O43374, (Mouse) Q6PFQ7
Entrez Gene ID: (Human) 10156, (Mouse) 54153, (Rat) 288589
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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