Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described.
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Protein Aliases: GAP1 like protein; Ras GTPase-activating-like protein; RAS protein activator like 1; RasGAP-activating-like protein 1
Gene Aliases: MRASAL; RASAL; RASAL1