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Proteintech
RASGAP Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-12935
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RASGAP fusion protein Ag3906
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MMAAEAGSE EGGPVTAGAG GGGAAAGSSA YPAVCRVKIP AALPVAAAPY PGLVETGVAG TLGGGAALGS EFLGAGSVAG ALGGAGLTGG GTAAGVAGAA AGVAGAAVAG PSGDMALTKL PTSLLAETLG PGGGFPPLPP PPYLPPLGAG LGTVDEGDSL DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES DRRPGSFVLS FLSQMNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV HNELEDGWMW VTNLRTDEQG L
Target Information
TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 4,8, and 10. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GAP; GTPase-activating protein; p120 RAS GTPase activating protein; p120-rasGAP; p120GAP; Ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RAS p21 protein activator 1; rasGAP; triphosphatase-activating protein
Gene Aliases: CM-AVM; CMAVM; GAP; GAPX; p120; p120GAP; p120RASGAP; PKWS; RASA; RASA1; RASGAP
UniProt ID: (Human) P20936, (Rat) P50904
Entrez Gene ID: (Human) 5921, (Rat) 25676, (Mouse) 218397
glycoprotein binding
GTPase activator activity
receptor binding
protein binding
potassium channel inhibitor activity
GTPase binding
platelet-derived growth factor receptor binding
kinase binding
protein kinase binding
receptor tyrosine kinase binding
protein complex binding
ion channel binding
scaffold/adaptor protein
GTPase-activating protein
MAPK cascade
mitotic cytokinesis
vasculogenesis
negative regulation of cell-matrix adhesion
negative regulation of cell adhesion
signal transduction
regulation of cell shape
embryo development
regulation of actin filament polymerization
intracellular signal transduction
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
ephrin receptor signaling pathway
blood vessel morphogenesis
regulation of RNA metabolic process
cell adhesion
actin cytoskeleton organization
positive regulation of protein phosphorylation
cellular response to platelet-derived growth factor stimulus
positive regulation of glucose import
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to epidermal growth factor stimulus
activation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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