Invitrogen
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:10-1:50 | - |
Flow Cytometry (Flow) |
1:10-1:50 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Published species |
Human |
Host/Isotype |
Rabbit / Ig |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide between 495-521 amino acids from the central region of human RASGRP1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.8 mg/mL |
Purification |
Protein A, Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2543250 |
This antibody is predicted to react with mouse and rat based on sequence homology.
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Calcium and DAG-regulated guanine nucleotide exchange factor II; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1
Gene Aliases: CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; RASGRP1; V
UniProt ID: (Human) O95267
Entrez Gene ID: (Human) 10125
Molecular Function:
guanyl-nucleotide exchange factor
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