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Product Details
14557-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
RBAP48 Fusion Protein Ag6110 (1-425 aa encoded by BC053904) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MADKEAAFD DAVEERVINE EYKIWKKNTP FLYDLVMTHA LEWPSLTAQW LPDVTRPEGK DFSIHRLVLG THTSDEQNHL VIASVQLPND DAQFDASHYD SEKGEFGGFG SVSGKIEIEI KINHEGEVNR ARYMPQNPCI IATKTPSSDV LVFDYTKHPS KPDPSGECNP DLRLRGHQKE GYGLSWNPNL SGHLLSASDD HTICLWDISA VPKEGKVVDA KTIFTGHTAV VEDVSWHLLH ESLFGSVADD QKLMIWDTRS NNTSKPSHSV DAHTAEVNCL SFNPYSEFIL ATGSADKTVA LWDLRNLKLK LHSFESHKDE IFQVQWSPHN ETILASSGTD RRLNVWDLSK IGEEQSPEDA EDGPPELLFI HGGHTAKISD FSWNPNEPWV ICSVSEDNIM QVWQMAENIY NDEDPEGSVD PEGQGS (1-425 aa encoded by B C053904)
Target Information
RbAp48-11G10 recognizes full length RbAp48, a 48 kDa nuclear protein first isolated by its ability to interact with the carboxyl-terminus of the retinoblastoma protein (Rb). It is a member of the WD (Trp-Asp) repeat family of proteins. RbAp48 is one of the three subunits of CAF-1, can bind to histone H4 and is a subunit of human histone deacetylase HD1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAF-1 p48 subunit; CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; Chromatin assembly factor 1 subunit C; Chromatin assembly factor I p48 subunit; chromatin assembly factor/CAF-1 p48 subunit; Histone-binding protein RBBP4; MSI1 protein homolog; Nucleosome-remodeling factor subunit RBAP48; RBBP-4; retinoblastoma binding protein 4; Retinoblastoma-binding protein 4; Retinoblastoma-binding protein p48
Gene Aliases: lin-53; mRbAp48; NURF55; RBAP48; RBBP4
UniProt ID: (Human) Q09028, (Mouse) Q60972
Entrez Gene ID: (Human) 5928, (Rat) 313048, (Mouse) 19646
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
chromatin remodeling
metabolic process
chromatin assembly
ATP-dependent chromatin remodeling
response to growth hormone
DNA replication
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
negative regulation of cell proliferation
histone deacetylation
CENP-A containing nucleosome assembly
negative regulation of gene expression, epigenetic
regulation of cell cycle
regulation of signal transduction by p53 class mediator
chromatin modification
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
histone deacetylase activity
protein binding
DNA-dependent ATPase activity
nucleosomal DNA binding
histone binding
histone deacetylase binding
molecular_function
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