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Immunogen sequence: MNLELLESF GQNYPEEADG TLDCISMALT CTFNRWGTLL AVGCNDGRIV IWDFLTRGIA KIISAHIHPV CSLCWSRDGH KLVSASTDNI VSQWDVLSGD CDQRFRFPSP ILKVQYHPRD QNKVLVCPMK SAPVMLTLSD SKHVVLPVDD DSDLNVVASF DRRGEYIYTG NAKGKILVLK TDSQDLVASF RVTTGTSNTT AIKSIEFARK GSCFLINTAD RIIRVYDGRE ILTCGRDGEP EPMQKLQDLV NRTPWKKCCF SGDGEYIVAG SARQHALYIW EKSIGNLVKI LHGTRGELLL DVAWHPVRPI IASISSGVVS IWAQNQVE (1-327 aa encoded by BC037284)
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
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Protein Aliases: RBBP 5; RBBP-5; RBQ 3; retinoblastoma binding protein 5; Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWD1, Set1c WD40 repeat protein, homolog
Gene Aliases: RBBP5; RBQ3; SWD1
UniProt ID: (Human) Q15291
Entrez Gene ID: (Human) 5929