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RBM10 Polyclonal Antibody

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RBM10 Antibody in Western Blot (WB) — Human brain tissue were subjected to SDS PAGE followed by western blot with 14423-1-AP (RBM10 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RBM10 Antibody in Immunoprecipitation (IP) — IP result of anti-RBM10 (IP:14423-1-AP, 4ug; Detection:14423-1-AP 1:800) with mouse brain tissue lysate 4000ug.

Product Details

14423-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 1 publication 1 publication
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	RBM10 Fusion Protein Ag5788 (601-930 aa encoded by BC024153) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.42 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: QSQQYLYWD GERRTYVPAL EQSADGHKET GAPSKEGKEK KEKHKTKTAQ QIAKDMERWA RSLNKQKENF KNSFQPISSL RDDERRESAT ADAGYAILEK KGALAERQHT SMDLPKLASD DRPSPPRGLV AAYSGESDSE EEQERGGPER EEKLTDWQKL ACLLCRRQFP SKEALIRHQQ LSGLHKQNLE IHRRAHLSEN ELEALEKNDM EQMKYRDRAA ERREKYGIPE PPEPKRRKYG GISTASVDFE QPTRDGLGSD NIGSRMLQAM GWKEGSGLGR KKQGIVTPIE AQTRVRGSGL GARGSSYGVT STESYKETLH KTMVTRFNEA Q (601-930 aa encoded by BC024153)

Target Information

The protein encoded by this gene contains RNA recognition motif found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. In vitro studies showed that the rat homolog bound to RNA homopolymers, with a preference for G and U polyribonucleotides. This gene is part of a gene cluster on chromosome Xp11.23, and its 3' end lies within 20 kb upstream of UBE1. Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA.

BMC molecular biology

Sutherland LC,Thibault P,Durand M,Lapointe E,Knee JM,Beauvais A,Kalatskaya I,Hunt SC,Loiselle JJ,Roy JG,Tessier SJ,Ybazeta G,Stein L,Kothary R,Klinck R,Chabot B

Thu Jul 20 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: G patch domain-containing protein 9; rna-binding; RNA-binding motif protein 10; RNA-binding protein 10; RNA-binding protein S1-1; S1-1; S1-1 protein from liver

Gene Aliases: DXS8237E; E430039K10Rik; GPATC9; GPATCH9; KIAA0122; RBM10; S1-1; TARPS; ZRANB5

UniProt ID: (Human) P98175, (Rat) P70501, (Mouse) Q99KG3

Entrez Gene ID: (Human) 8241, (Rat) 64510, (Mouse) 236732

Function(s)

negative regulation of transcription from RNA polymerase II promoter negative regulation of cell proliferation regulation of smooth muscle cell apoptotic process positive regulation of smooth muscle cell apoptotic process negative regulation of mRNA splicing, via spliceosome 3'-UTR-mediated mRNA stabilization regulation of alternative mRNA splicing, via spliceosome mRNA processing biological_process RNA splicing regulation of apoptotic process

Process(es)

nucleotide binding protein binding zinc ion binding protein complex binding identical protein binding poly(A) RNA binding nucleic acid binding RNA binding metal ion binding

RBM10 Polyclonal Antibody

Product Details

14423-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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