Immunogen sequence: RGARDRTPPLL YRDRDRDLYP DSDWVPPPPP VRERSTRTAA TSVPAYEPLD SLDRRRDGWS LDRDRGDRDL PSSRDQPRKR RLPEESGGRH LDRSPESDRP RKRHC
Highest antigen sequence identity to the following orthologs - mouse 91%, rat 93%.
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: one twenty two protein; one twenty-two; One-twenty two protein 1; OTT; OTT1; putative RNA-binding protein 15; RNA-binding motif protein 15; RNA-binding protein 15; SPEN
Gene Aliases: OTT; OTT1; RBM15; SPEN
UniProt ID: (Human) Q96T37
Entrez Gene ID: (Human) 64783