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Product Details
16484-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RBM28 Fusion Protein Ag9606 (411-760 aa encoded by BC013889)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QLKVDLAVT RDEAAKLQTT KVKKPTGTRN LYLAREGLIR AGTKAAEGVS AADMAKRERF ELLKHQKLKD QNIFVSRTRL CLHNLPKAVD DKQLRKLLLS ATSGEKGVRI KECRVMRDLK GVHGNMKGQS LGYAFAEFQE HEHALKALRL INNNPEIFGP LKRPIVEFSL EDRRKLKMKE LRIQRSLQKM RSKPATGEPQ KGQPEPAKDQ QQKAAQHHTE EQSKVPPEQK RKAGSTSWTG FQTKAEVEQV ELPDGKKRRK VLALPSHRGP KIRLRDKGKV KPVHPKKPKP QINQWKQEKQ QLSSEQVSRK KAKGNKTETR FNQLVEQYKQ KLLGPSKGAP LAKRSKWFDS (411-760 aa encoded by BC013889)
Target Information
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2810480G15Rik; RNA-binding motif protein 28; RNA-binding protein 28
Gene Aliases: 2810480G15Rik; AI503051; ANES; RBM28
UniProt ID: (Human) Q9NW13, (Mouse) Q8CGC6
Entrez Gene ID: (Human) 55131, (Rat) 312182, (Mouse) 68272
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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