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Proteintech
RBX1 Polyclonal Antibody
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Product Details
14895-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Arthropod,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RBX1 Fusion Protein Ag6685 (1-108 aa encoded by BC001466)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAAMDVDT PSGTNSGAGK KRFEVKKWNA VALWAWDIVV DNCAICRNHI MDLCIECQAN QASATSEECT VAWGVCNHAF HFHCISRWLK TRQVCPLDNR EWEFQKYGH (1-108 aa encoded by BC001466 )
Target Information
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RBX1; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RBX1; Regulator of cullins 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; ROC1; unnamed protein product; ZYP protein
Gene Aliases: BA554C12.1; RBX1; RNF75; ROC1
UniProt ID: (Human) P62877
Entrez Gene ID: (Human) 9978
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
NEDD8 transferase activity
ubiquitin protein ligase binding
ubiquitin-ubiquitin ligase activity
macromolecular complex binding
metal ion binding
binding, bridging
RNA polymerase II sequence-specific DNA binding transcription factor binding
ubiquitin protein ligase activity
NEDD8 ligase activity
cullin family protein binding
autophagosome assembly
G1/S transition of mitotic cell cycle
MAPK cascade
protein polyubiquitination
mitophagy
epithelial to mesenchymal transition
DNA repair
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
protein monoubiquitination
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
lysosome organization
spermatogenesis
regulation of mitotic cell cycle
insulin receptor signaling pathway
negative regulation of autophagy
positive regulation of autophagy
protein ubiquitination
cytokine-mediated signaling pathway
protein catabolic process
DNA damage response, signal transduction by p53 class mediator
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
cellular response to nutrient levels
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of type I interferon production
positive regulation of type I interferon production
cellular response to insulin stimulus
cellular response to amino acid starvation
cellular response to oxidative stress
cellular response to UV
mRNA cleavage involved in gene silencing by miRNA
p38MAPK cascade
TORC1 signaling
T cell activation
signal transduction in response to DNA damage
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
post-translational protein modification
protein neddylation
positive regulation of translation
positive regulation of protein catabolic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin receptor signaling pathway
type I interferon signaling pathway
cellular response to chemical stress
renal sodium ion absorption
protein K48-linked ubiquitination
cellular response to amino acid stimulus
negative regulation of canonical Wnt signaling pathway
base-excision repair, AP site formation via deaminated base removal
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
RNA polymerase II transcription initiation surveillance
regulation of cellular response to insulin stimulus
negative regulation of macromitophagy
negative regulation of signal transduction by p53 class mediator
positive regulation of protein autoubiquitination
negative regulation of response to oxidative stress
positive regulation of epithelial cell apoptotic process
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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