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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid peptide near the carboxy terminus of human RC3H1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||5 ug/ml|
|Western Blot (WB)||1 - 2 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is Hela cell lysate.
PA5-34519 can be used with blocking peptide PEP-1562.
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
probable E3 ubiquitin-protein ligase Roquin; protein Sanroque; RC3H1; RING CCCH (C3H) domains 1; RING finger and C3H zinc finger protein 1; Ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; ring finger and CCCH-type zinc finger domains 1; RING finger protein 198; RNF198; roquin; roquin-1
5730557L09Rik; Gm551; KIAA2025; mKIAA2025; N28103; RC3H1; RGD1563512; RNF198; ROQUIN