Immunogen sequence: PPSAPEPAPP YLDHYPPYLQ ERVVNSQYGT QPQQYPPIYP SHYDGRRVYP APSYTREEIF RESPIPIEIP PAAVPSYVPE SRERYQQIES YYPVAPHPTQ IRP
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 31%.
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
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Protein Aliases: probable E3 ubiquitin-protein ligase Roquin; RC3H1; RING finger and C3H zinc finger protein 1; Ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; RING finger protein 198; RNF198; Roquin; Roquin-1
Gene Aliases: KIAA2025; RC3H1; RNF198; ROQUIN
UniProt ID: (Human) Q5TC82
Entrez Gene ID: (Human) 149041