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Proteintech
RCAN2 Polyclonal Antibody
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Product Details
12900-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RCAN2 Fusion Protein Ag3597 (35-201 aa encoded by BC038509)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LFRTYDDCV TFQLFKSFRR VRINFSNPKS AARARIELHE TQFRGKKLKL YFAQVQTPET DGDKLHLAPP QPAKQFLISP PSSPPVGWQP INDATPVLNY DLLYAVAKLG PGEKYELHAG TESTPSVVVH VCDSDIEEEE DPKTSPKPKI IQTRRPGLPP SVSNWAAC (35-201 aa encoded by BC038509 )
Target Information
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcineurin inhibitory protein ZAKI-4; Calcipressin-2; Down syndrome candidate region 1-like 1; Down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; MCIP2; myocyte-enriched calcineurin interactin protein 2; Myocyte-enriched calcineurin-interacting protein 2; Regulator of calcineurin 2; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4
Gene Aliases: CSP2; DSCR1L1; MCIP2; RCAN2; RCN2; ZAKI-4; ZAKI4
UniProt ID: (Human) Q14206, (Mouse) Q9JHG2
Entrez Gene ID: (Human) 10231, (Mouse) 53901
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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