Peptide sequence: WLYLAVFVGL YYLLHWYRER QVLSHLRDKY VFITGCDSGF GKLLARQLDA
Sequence homology: Cow: 86%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 93%; Rat: 86%
Retinol dehydrogenase 16 (RDH16) is an oxidoreductase with a preference for NAD. It oxidizes all-trans-retinol and 13-cis-retinol to the corresponding aldehydes. RDH16 has higher activity towards CRBP-bound retinol than with free retinol. It oxidizes 3-alpha-hydroxysteroids and also oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. RDH16 can also catalyze the reverse reaction.
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Protein Aliases: 29 kDa protein; Cis-retinol androgen dehydrogenase 1; cis-retinol/androgen dehydrogenase 1; hRDH-E; Human epidermal retinol dehydrogenase; Microsomal NAD(+)-dependent retinol dehydrogenase 4; microsomal NAD+-dependent retinol dehydrogenase 4; Retinol dehydrogenase 16; retinol dehydrogenase 16 (all-trans and 13-cis); Retinol dehydrogenase 16 (all-trans); Retinol dehydrogenase 2; retinol dehydrogenase 6; Retinol dehydrogenase type 1; retinol dehydrogenase type 2; retinol dehydrogenase type 6; Retinol dehydrogenase type II; retinol dehydrogenase type II (RODH II); RODH II; RODH-4; SDR9C8; Short chain dehydrogenase/reductase family 9C member 8; short chain dehydrogenase/reductase family 9C, member 8; Sterol/retinol dehydrogenase
Gene Aliases: BOS_5613; CRAD; CRAD1; Rdh1; RDH16; Rdh2; Rdh6; RODH-4; Rodh1; RODH4; RoDHII; SDR9C8