This antibody is predicted to react with bovine, chicken and rat based on sequence homology.
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-cell associated protein; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; Bap37; BCAP37; D-prohibitin; MGC117268; PHB2; PNAS-141; Prohibitin-2; REA; Repressor of estrogen receptor activity
Gene Aliases: AU044498; BAP; Bap37; BCAP37; hBAP; p22; PHB2; PNAS-141; REA