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REA Polyclonal Antibody
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FIGURE: 1 / 3
REA Antibody (PA5-70526) in WB
Western blot was performed using Anti-Prohibitin2 Polyclonal Antibody (Product # PA5-70526) and a 30 kDa band corresponding to Prohibitin2 , along with an uncharacterized band(*), was observed across cell lines and tissue tested. Whole cell extracts (30 µg lysate) of Caco-2 (Lane 1), Hep G2 (Lane 2), T-47D (Lane 3), A-431 (Lane 4), HeLa (Lane 5), NIH/3T3 (Lane 6) and PC-12 (Lane 7) and tissue extract of Mouse Heart (Lane 8) were electrophoresed using NuPAGE™ 12% Bis-Tris Protein Gel (Product # NP0341BOX). Resolved proteins were then transf... View More
Product Details
PA5-70526
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human REA (aa 191-240)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 93%
Immunogen is a synthetic peptide located within the following region: REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE
Target Information
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; MGC117268; phb2; Prohibitin-2; Repressor of estrogen receptor activity
Gene Aliases: AU044498; BAP; Bap37; Bcap37; Phb2; REA
UniProt ID: (Mouse) O35129
Entrez Gene ID: (Mouse) 12034
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
mitochondrion organization
sister chromatid cohesion
positive regulation of exit from mitosis
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of mammary gland epithelial cell proliferation
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
mammary gland branching involved in thelarche
mammary gland alveolus development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle G1/S phase transition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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