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Proteintech
REC8 Polyclonal Antibody
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Product Details
10793-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
REC8 Fusion Protein Ag1250 (188-548 aa encoded by BC010887)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human REC8. This antibody can recognize the monomeric, non-phosphorylated form (63-70 kDa) of REC8 and other forms(80-100 kDa) which represent either post translationally modified forms or alternative transcript products.
Immunogen sequence: VLPPEAITI LEAEPIRMLE IEGERELPEV SRRELDLLIA EEEEAILLEI PRLPPPAPAE VEGIGEALGP EELRLTGWEP GALLMEVTPP EELRLPAPPS PERRPPVPPP PRRRRRRRLL FWDKETQISP EKFQEQLQTR AHCWECPMVQ PPERTIRGPA ELFRTPTLSG WLPPELLGLW THCAQPPPKA LRRELPEEAA AEEERRKIEV PSEIEVPREA LEPSVPLMVS LEISLEAAEE EKSRISLIPP EERWAWPEVE APEAPALPVV PELPEVPMEM PLVLPPELEL LSLEAVHRAV ALELQANREP DFSSLVSPLS PRRMAARVFY LLLVLSAQQI LHVKQEKPYG RLLIQPGPRF H (188-548 aa encoded by BC010887)
Target Information
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cohesin Rec8p; cohesion rec8p; hHR21spB; human homolog of rad21, S. pombe; kleisin-alpha; meiotic cohesion Rec8; meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family; Meiotic recombination protein REC8 homolog; meiotic recombination protein REC8-like 1; REC8 homolog; REC8-like 1; REC8L1; recombination and sister chromatid cohesion protein homolog; unnamed protein product
Gene Aliases: HR21spB; Mei8; mrec; REC8; REC8L1; Rec8p
UniProt ID: (Human) O95072, (Mouse) Q8C5S7
Entrez Gene ID: (Human) 9985, (Mouse) 56739
double-strand break repair via homologous recombination
oocyte maturation
double-strand break repair
chromosome segregation
sister chromatid cohesion
synapsis
synaptonemal complex assembly
reciprocal meiotic recombination
male meiosis I
spermatogenesis
spermatid development
fertilization
meiotic sister chromatid cohesion
meiotic cell cycle
seminiferous tubule development
meiotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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