Immunogen sequence: PSPFDIPQIR HLLEAAIPER VEEIPPEVPT EPREPERIPV TVLPPEAITI LEAEPIRMLE IEGERELPEV SRRELDLLI
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 68%.
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cohesin Rec8p; cohesion rec8p; human homolog of rad21, S. pombe; kleisin-alpha; meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family; Meiotic recombination protein REC8 homolog; meiotic recombination protein REC8-like 1; REC8 homolog; REC8-like 1; REC8L1; recombination and sister chromatid cohesion protein homolog
Gene Aliases: HR21spB; REC8; REC8L1; Rec8p
UniProt ID: (Human) O95072
Entrez Gene ID: (Human) 9985