Immunogen sequence: WLQRCHSEVP DFLGAPKACR PDLGSEESQL LIPGESAVLG PGAGSQGPEA SAFQEVSIRV GSPQPSSSGG EKRRWNEEPW ESPAQVQQES SQAGPPSEGA GAVAVEEDPP GE
Highest antigen sequence identity to the following orthologs: Mouse - 47%, Rat - 45%.
The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes.
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Protein Aliases: ATP-dependent DNA helicase Q4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ helicase-like 4; RecQ protein-like 4; RecQ4; RTS
Gene Aliases: RECQ4; RECQL4
UniProt ID: (Human) O94761
Entrez Gene ID: (Human) 9401
Molecular Function: DNA helicase