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Invitrogen
REG3B Polyclonal Antibody
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FIGURE: 1 / 1
REG3B Antibody (PA5-47700) in IHC (F)
Immunohistochemical analysis of REG3B in immersion fixed frozen sections of mouse small intestine. Samples were incubated in REG3B polyclonal antibody (Product # PA5-47700) using a dilution of 10 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue).
Product Details
PA5-47700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse Reg3B Glu27-Gly175
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 75% cross-reactivity with recombinant rat (rr) Reg3B is observed. In Western blots, approximately 30% cross-reactivity with rrReg3B is observed. In direct ELISAs and Western blots, less than 1% cross-reactivity with rrReg3A, recombinant mouse (rm) Reg3A, and rmReg3G is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The REG3B gene encodes a protein that is part of the regenerating islet-derived (Reg) family, with significant roles in antimicrobial activity and tissue repair. REG3B is primarily expressed in the pancreas and is implicated in pancreatic regeneration, playing a critical role in conditions such as diabetes and pancreatitis. It exhibits potential therapeutic benefits in tissue injury and inflammatory disorders, including inflammatory bowel disease and acute liver injury. REG3B promotes acinar-to-ductal metaplasia through the activation of the RAS-RAF-MEK-ERK signaling pathway, suggesting its involvement in the early stages of pancreatic ductal adenocarcinoma development. Additionally, REG3B has been identified as an essential regulator of macrophage trafficking in cardiac healing post-myocardial ischemia, aiding in the recruitment and expansion of myeloid cells. Research aims to target REG3B and its receptors to interrupt pathological processes, offering promising avenues for treatment of pancreatic and extrapancreatic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pancreatitis-associated protein 1; Reg III-beta; REG-3-beta; Regenerating islet-derived protein 3-beta; Regenerating islet-derived protein III-beta; RegIII (beta)
Gene Aliases: HIP; Pap; PAP1; REG-III; Reg3b
UniProt ID: (Mouse) P35230
Entrez Gene ID: (Mouse) 18489
positive regulation of protein phosphorylation
acute-phase response
inflammatory response
positive regulation of cell proliferation
negative regulation of neuron apoptotic process
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
negative regulation of cell death
negative regulation of hydrogen peroxide-induced neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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