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Invitrogen
REG3B Polyclonal Antibody
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FIGURE: 1 / 2
REG3B Antibody (PA5149809) in WB
Western blot analysis of REG3B in Lane 1: Mouse Pancreas lysate; Lane 2: Rat Pancreas lysate; Lane 3: Porcine Pancreas lysate. Samples were incubated with REG3B Polyclonal (Product # PA5149809) antibody using a dilution of 0.5 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (0.2 µg/mL).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5149809
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Regenerating Islet Derived Protein 3 Beta (REG3b) (Glu27-Gly175)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The REG3B gene encodes a protein that is part of the regenerating islet-derived (Reg) family, with significant roles in antimicrobial activity and tissue repair. REG3B is primarily expressed in the pancreas and is implicated in pancreatic regeneration, playing a critical role in conditions such as diabetes and pancreatitis. It exhibits potential therapeutic benefits in tissue injury and inflammatory disorders, including inflammatory bowel disease and acute liver injury. REG3B promotes acinar-to-ductal metaplasia through the activation of the RAS-RAF-MEK-ERK signaling pathway, suggesting its involvement in the early stages of pancreatic ductal adenocarcinoma development. Additionally, REG3B has been identified as an essential regulator of macrophage trafficking in cardiac healing post-myocardial ischemia, aiding in the recruitment and expansion of myeloid cells. Research aims to target REG3B and its receptors to interrupt pathological processes, offering promising avenues for treatment of pancreatic and extrapancreatic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pancreatic beta cell growth factor; Pancreatitis-associated protein 1; peptide 23; reg III-beta; REG-2; REG-3-beta; regenerating islet-derived 3 beta; regenerating islet-derived protein III-beta; regenerating protein; RegIII (beta)
Gene Aliases: HIP; Pap; PAP1; REG-III
UniProt ID: (Rat) P25031, (Mouse) P35230
Entrez Gene ID: (Rat) 24618, (Mouse) 18489
positive regulation of protein phosphorylation
signal transduction
midgut development
female pregnancy
positive regulation of cell proliferation
response to wounding
response to bacterium
positive regulation of keratinocyte proliferation
response to nutrient levels
response to estradiol
response to starvation
negative regulation of apoptotic process
response to peptide hormone
estrous cycle
negative regulation of keratinocyte differentiation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to tumor necrosis factor
cellular response to xenobiotic stimulus
negative regulation of inflammatory response to wounding
negative regulation of cellular response to oxidative stress
cellular response to L-arginine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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