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Invitrogen
REG3G Polyclonal Antibody
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Product Details
PA5-120793
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 27-174 of mouse REG3G (NP_0353901)
Conjugate
Form
Liquid
Concentration
3.10 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: BxPC-3, U-87MG, Rat skeletal muscle. The target is usually found in the following locations: Cytoplasm, Secreted.
Immunogen sequence: EVAKKDAPSS RSSCPKGSRA YGSYCYALFS VSKNWYDADM ACQKRPSGHL VSVLSGAEAS FLSSMIKSSG NSGQYVWIGL HDPTLGYEPN RGGWEWSNAD VMNYINWETN PSSSSGNHCG TLSRASGFLK WRENYCNLEL PYVCKFKA
Target Information
REG3G, also known as regenerating islet-derived 3 gamma, is a gene encoding an antimicrobial peptide crucial for maintaining intestinal homeostasis and regulating host-microbiome interactions. The protein produced by REG3G belongs to the C-type lectin family and is primarily expressed in the gut, where it plays a significant role in defending against bacterial infections. REG3G helps maintain gut barrier function and immune responses, acting in collaboration with interleukin 22 (IL-22), which regulates its expression. This gene is downregulated during chronic ethanol exposure, suggesting an influence on susceptibility to alcoholic liver disease. REG3G is also involved in glucose metabolism, with evidence showing that its administration improves glucose tolerance, potentially through actions mediated by its receptor, Extl3. Furthermore, REG3G has been identified as a nociceptor-enriched hormone, which protects against endotoxic shock by modulating both local and systemic immunity. This diverse functionality underscores the gene's importance in immune modulation, gut physiology, and metabolic processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: generating islet-derived, mouse homolog 3 gamma; Pancreatitis-associated protein 1B; Pancreatitis-associated protein 3; Pancreatitis-associated protein IB; PAP IB; PAP-1B; REG III; Reg III-gamma; REG-3-gamma; REG-3gamma; REG3gamma; regenerating gene III; regenerating islet-derived 3 gamma; regenerating islet-derived protein 3 gamma; Regenerating islet-derived protein 3-gamma; Regenerating islet-derived protein III-gamma; RegIII (gamma)
Gene Aliases: AI449515; LPPM429; PAP IB; PAP-1B; PAP1B; Pap3; PAPIB; PAPIII; REG III; REG-III; REG3G; UNQ429; UNQ429/PRO162
UniProt ID: (Human) Q6UW15, (Mouse) O09049, (Rat) P42854
Entrez Gene ID: (Human) 130120, (Mouse) 19695, (Rat) 24620
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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