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Proteintech
RELN Polyclonal Antibody
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FIGURE: 1 / 6
RELN Antibody (20689-1-AP) in IHC (P)
Dual immunofluorescent analysis of ( 4% PFA) fixed mouse brain tissue using 20689-1-AP (RELN antibody) at dilution of 1:50 and 66564-1-IG (Tbr1 antibody), further stained with Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) for 20689-1-AP and Alexa Fluor 594-Conjugated AffiniPure Goat Anti-Mouse IGG (H+L) for 66564-1-IG.
Product Details
20689-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: extracellular matrix serine protease; Reeler protein; Reelin
Gene Aliases: ETL7; LIS2; PRO1598; reeler; RELN; RL
UniProt ID: (Human) P78509, (Mouse) Q60841
Entrez Gene ID: (Human) 5649, (Mouse) 19699
protein serine/threonine/tyrosine kinase activity
serine-type peptidase activity
metal ion binding
lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
protein binding
peptidase activity
hydrolase activity
cell adhesion molecule
extracellular matrix glycoprotein
extracellular matrix protein
cell morphogenesis involved in differentiation
neuron migration
proteolysis
cell adhesion
axon guidance
central nervous system development
brain development
long-term memory
associative learning
glial cell differentiation
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
dendrite development
peptidyl-tyrosine phosphorylation
spinal cord patterning
ventral spinal cord development
hippocampus development
cerebral cortex tangential migration
layer formation in cerebral cortex
positive regulation of TOR signaling
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
positive regulation of protein kinase activity
response to pain
positive regulation of peptidyl-tyrosine phosphorylation
regulation of behavior
modulation of synaptic transmission
positive regulation of small GTPase mediated signal transduction
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
positive regulation of synapse maturation
NMDA glutamate receptor clustering
postsynaptic density protein 95 clustering
receptor localization to synapse
lateral motor column neuron migration
positive regulation of long-term synaptic potentiation
positive regulation of lateral motor column neuron migration
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
multicellular organism development
locomotory behavior
regulation of gene expression
cell migration
dentate gyrus development
cerebral cortex development
forebrain development
protein localization to synapse
thyroid hormone metabolic process
postsynaptic density assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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