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REST/NRSF Polyclonal Antibody, FITC

View all (17) REST antibodies

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REST/NRSF Polyclonal Antibody, FITC

Product Details

REST-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 1000-1097 on human REST protein.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Neural-restrictive silencer factor; neuron restrictive silencer factor; RE1-silencing transcription factor; repressor binding to the X2 box; transcription factor; X2 box repressor; zinc finger transcription factor REST protein

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Gene Aliases: 2610008J04Rik; AA407358; DFNA27; GINGF5; HGF5; NRSF; REST; REST4; WT6; XBR

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UniProt ID: (Human) Q13127, (Mouse) Q8VIG1, (Rat) O54963

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Entrez Gene ID: (Human) 5978, (Mouse) 19712, (Rat) 83618

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding identical protein binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding core promoter binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding transcription factor binding outward rectifier potassium channel activity protein complex binding transcription regulatory region DNA binding C2H2 zinc finger transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of alternative mRNA splicing, via spliceosome response to hypoxia hematopoietic progenitor cell differentiation response to ischemia chromatin remodeling regulation of transcription, DNA-templated response to stress regulation of gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of aldosterone biosynthetic process cellular response to stress somatic stem cell population maintenance positive regulation of programmed cell death negative regulation by host of viral transcription negative regulation of neuron differentiation positive regulation of neuron differentiation regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of calcium ion-dependent exocytosis negative regulation of insulin secretion negative regulation of neurogenesis neurological system process neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound auditory receptor cell stereocilium organization cardiac muscle cell myoblast differentiation cellular response to electrical stimulus cellular response to glucocorticoid stimulus neuronal stem cell population maintenance modification of synaptic structure positive regulation of stem cell population maintenance negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cortisol biosynthetic process negative regulation of dense core granule biogenesis negative regulation of mesenchymal stem cell differentiation negative regulation of amniotic stem cell differentiation transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter negative regulation of cell proliferation regulation of ion transmembrane transport cellular response to drug positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process histone H4 deacetylation potassium ion transmembrane transport
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