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RET Polyclonal Antibody
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FIGURE: 1 / 2
RET Antibody (BS-2793R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat adrenal gland; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with RET Polyclonal Antibody, Unconjugated (bs-2793R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes an... View More
Product Details
BS-2793R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RET, amino acids 1001-1114.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 12; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); cadherin-related family member 16; EC 2.7.10.1; ELKS; Hydroxyaryl protein kinase; kinase Ret; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; receptor tyrosine kinase; ret; RET ELE1; Ret gene for receptor tyrosin; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); RET receptor tyrosine kinase; unnamed protein product
Gene Aliases: c-Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51; RET9
UniProt ID: (Human) P07949, (Mouse) P35546, (Rat) G3V9H8
Entrez Gene ID: (Human) 5979, (Mouse) 19713, (Rat) 24716
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
calcium ion binding
protein binding
ATP binding
kinase activity
transferase activity
signaling receptor activity
transferase activity, transferring phosphorus-containing groups
molecular_function
transmembrane signal receptor
MAPK cascade
ureteric bud development
neural crest cell migration
embryonic epithelial tube formation
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
neuron cell-cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
axon guidance
posterior midgut development
positive regulation of gene expression
positive regulation of neuron projection development
regulation of cell adhesion
neuron differentiation
positive regulation of cell migration
membrane protein proteolysis
positive regulation of cell adhesion mediated by integrin
ureter maturation
glial cell-derived neurotrophic factor receptor signaling pathway
neuron maturation
positive regulation of MAPK cascade
positive regulation of cell size
positive regulation of transcription, DNA-templated
response to pain
enteric nervous system development
regulation of axonogenesis
positive regulation of protein kinase B signaling
Peyer's patch morphogenesis
cellular response to retinoic acid
positive regulation of metanephric glomerulus development
lymphocyte migration into lymphoid organs
GDF15-GFRAL signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
anatomical structure morphogenesis
positive regulation of neuron maturation
phosphorylation
peptidyl-tyrosine phosphorylation
innervation
response to drug
retina development in camera-type eye
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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