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Product Details
PA5-56169
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RFC2
Conjugate
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2646483
Product Specific Information
Immunogen sequence: PAPAFSKAPG SAGHYELPWV EKYRPVKLNE IVGNEDTVSR LEVFAREGNV PNIIIAGPPG TGKTTSILCL ARALLGPALK DAMLELNASN D
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Target Information
This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1 40 kDa subunit; Activator 1 40 kDa subunit; Activator 1 subunit 2; Activator 1 subunit C2; MGC3665; replication factor C (activator 1) 2, 40kDa; Replication factor C 40 kDa subunit; Replication factor C subunit 2; replication factor C, 40 kDa; RF-C 40 kDa subunit; RFC40
Gene Aliases: 2610008M13Rik; 40kDa; AI326953; Recc2; RFC2; RFC40
UniProt ID: (Human) P35250, (Mouse) Q9WUK4, (Rat) Q641W4
Entrez Gene ID: (Human) 5982, (Mouse) 19718, (Rat) 116468
Molecular Function:
DNA-directed DNA polymerase
telomere maintenance via recombination
DNA replication
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA gap filling
translesion synthesis
nucleotide-excision repair, DNA incision
error-prone translesion synthesis
DNA damage response, detection of DNA damage
error-free translesion synthesis
positive regulation of DNA-directed DNA polymerase activity
regulation of signal transduction by p53 class mediator
DNA-dependent DNA replication
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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