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Product Details
12687-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RFFL Fusion Protein Ag3380 (1-327 aa encoded by BC028424)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MWATCCNWF CLDGQPEEVP PPQGARMQAY SNPGYSSFPS PTGLEPSCKS CGAHFANTAR KQTCLDCKKN FCMTCSSQVG NGPRLCLLCQ RFRATAFQRE ELMKMKVKDL RDYLSLHDIS TEMCREKGEL VLLVLGQQPV ISQEDRTRAS TLSPDFPEQQ AFLTQPHSSM VPPTSPNLPS SSAQATSVPP AQVQENQQSI DSEDSFVPGR RASLSDLTDL EDIEGLTVRQ LKEILARNFV NYKGCCEKWE LMERVTRLYK DQKGLQHLGG AVPSGLEENL CKICMDSPID CVLLECGHMV TCTKCGKRMN ECPICRQYVI RAVHVFRS (1-327 aa encoded by BC028424)
Target Information
Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CARP-2; Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin-protein ligase rififylin; Fring; FYVE-RING finger protein SAKURA; rififylin; ring finger and FYVE like domain containing protein; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like; RING finger protein SAKURA; RING-type E3 ubiquitin transferase rififylin
Gene Aliases: 1700051E09Rik; 4930516L10Rik; BG080975; CARP-2; CARP2; FRING; RFFL; RIFIFYLIN; RNF189; RNF34L
UniProt ID: (Human) Q8WZ73, (Mouse) Q6ZQM0, (Rat) Q8CIN9
Entrez Gene ID: (Human) 117584, (Mouse) 67338, (Rat) 282844
protease binding
p53 binding
protein binding
zinc ion binding
ligase activity
protein kinase binding
ubiquitin protein ligase binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
molecular_function
ubiquitin-protein ligase
ubiquitin-dependent protein catabolic process
apoptotic process
regulation of fibroblast migration
negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of TOR signaling
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K48-linked ubiquitination
negative regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
intracellular protein transport
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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