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Proteintech
RFTN1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
24289-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RFTN1 Fusion Protein Ag17264 (29-374 aa encoded by BC100667)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.32 mg/mL
Amount
48 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ETKIDVSYE YRFLEFTTLS AAELPGSSAV RLASLRDLPA QLLELYQQGF SLAALHPFVQ PTHEREKTPL EHIFRAILIK KTDRSQKTDL HNEGYILELD CCSSLDHPTD QKLIPEFIKK IQEAASQGLK FVGVIPQYHS SVNSAGSSAP VSTANSTEDA RDAKNARGDH ASLENEKPGT GDVCSAPAGR NQSPEPSSGP RGEVPLAKQP SSPSGEGDGG ELSPQGVSKT LDGPESNPLE VHEEPLSGKM EIFTLFNKPK SHQKCRQYYP VTIPLHVSKN GQTVSGLDAN WLEHMSDHFR KGGMLVNAVF YLGIVNDSLH GLTDGVFIFE AVSTEDSKTI QGYDAIV (29-374 aa encoded by BC100667)
Target Information
Raftlin, also known as RFTN1 (raftlin, lipid raft linker 1), cell migration-inducing gene 2 protein, PIB10, PIG9 or MIG2, is a 578 amino acid cell membrane protein and lipid anchor that is essential for raft cell assembly and maintenance. A member of the raftlin family, Raftlin modulates B-cell antigen receptor-mediated signaling, TCR signals, and is involved in T cell-mediated immune responses. The gene encoding Raftlin maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell migration-inducing gene 2 protein; KIAA0084; MIG2; proliferation-inducing protein 10; proliferation-inducing protein 9; raft-linking protein; unnamed protein product
Gene Aliases: MIG2; PIB10; PIG9; RAFTLIN
UniProt ID: (Human) Q14699
Entrez Gene ID: (Human) 23180
membrane raft assembly
T cell antigen processing and presentation
protein transport into membrane raft
positive regulation of interleukin-17 production
dsRNA transport
toll-like receptor 3 signaling pathway
positive regulation of growth rate
response to exogenous dsRNA
T cell receptor signaling pathway
B cell receptor signaling pathway
protein localization to membrane raft
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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