PA5-30667 targets RFWD3 in WB applications and shows reactivity with Human samples.
The PA5-30667 immunogen is recombinant protein fragment corresponding to a region within amino acids 515 and 763 of Human RFWD3.
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E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
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Protein Aliases: E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RNF201
Gene Aliases: RFWD3; RNF201
UniProt ID: (Human) Q6PCD5
Entrez Gene ID: (Human) 55159