This target displays homology in the following species: Cow: 77%; Dog: 85%; Guinea Pig: 85%; Horse: 77%; Human: 77%; Mouse: 100%; Rat: 100%
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
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Protein Aliases: EF-C; EFC; Enhancer factor C; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; Regulatory factor X 1; regulatory factor X, 1 (influences HLA class II expression); regulatory factor X1; RFX; trans-acting regulatory factor 1; Transcription factor RFX1; vregulatory factor X, 1 (influences HLA class II expression)
Gene Aliases: AI047719; AI385641; EFC; RFX; RFX1
Molecular Function: transcription factor