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Product Details
PA5-61899
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RFXANK. Recombinant protein control fragment (Product #RP-101105).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646499
Product Specific Information
Immunogen sequence: TQPAEDLIQT QQTPASELGD PEDPGEEAAD GSDTVVLSLF PCTPEPVNPE PDASVSSPQ
Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 66%.
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ankyrin repeat family A protein 1; ankyrin repeat-containing regulatory factor X-associated protein; DNA-binding protein RFXANK; Regulatory factor X subunit B; Regulatory factor X-associated ankyrin-containing protein; RFX-B; RFX-Bdelta4
Gene Aliases: ANKRA1; BLS; F14150_1; RFX-B; RFXANK; RFXB
UniProt ID: (Human) O14593
Entrez Gene ID: (Human) 8625
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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