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Proteintech
RGMA Polyclonal Antibody
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Product Details
12387-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RGMA Fusion Protein Ag3058 (136-485 aa encoded by BC015886)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SAVHGIEDL MSQHNCSKDG PTSQPRLRTL PPAGDSQERS DSPEICHYEK SFHKHSATPN YTHCGLFGDP HLRTFTDRFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSA ATATSKLTII FKNFQECVDQ KVYQAEMDEL PAAFVDGSKN GGDKHGANSL KITEKVSGQH VEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDWDS QGLYLCLRGC PLNQQIDFQA FHTNAEGTGA RRLAAASPAP TAPETFPYET AVAKCKEKLP VEDLYYQACV FDLLTTGDVN FTLAAYYALE DVKMLHSNKD KLHLYERTRD LPGRAAAGLP LAPRPLLGAL VPLLALLPVF C (136-485 aa encoded by BC015886)
Target Information
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Repulsive guidance molecule A; RGM domain family member A; RGM domain family, member A
Gene Aliases: BC059072; C230063O06; RGM; RGMA
UniProt ID: (Human) Q96B86, (Mouse) Q6PCX7
Entrez Gene ID: (Human) 56963, (Rat) 308739, (Mouse) 244058
neural tube closure
BMP signaling pathway
regulation of BMP signaling pathway
positive regulation of protein phosphorylation
positive regulation of neuron projection development
negative regulation of neuron projection development
negative regulation of collateral sprouting
negative regulation of axon regeneration
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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