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Invitrogen
RGMA Polyclonal Antibody
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Product Details
PA5-113169
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Repulsive guidance molecule A protein (153-408AA)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Repulsive guidance molecule A; repulsive guidance molecule family member a; RGM domain family member A; RGM domain family, member A; unnamed protein product
Gene Aliases: BC059072; C230063O06; RGM; RGMA
UniProt ID: (Human) Q96B86, (Mouse) Q6PCX7
Entrez Gene ID: (Human) 56963, (Mouse) 244058
neural tube closure
membrane protein ectodomain proteolysis
positive regulation of macromolecule metabolic process
positive regulation of neuron projection development
negative regulation of neuron projection development
BMP signaling pathway
regulation of BMP signaling pathway
neuron projection development
positive regulation of transcription from RNA polymerase II promoter
negative regulation of collateral sprouting
negative regulation of axon regeneration
positive regulation of membrane protein ectodomain proteolysis
regulation of primary metabolic process
positive regulation of protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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