Recommended positive controls: Jurkat.
Predicted reactivity: Cow: 81%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Rabbit: 90%; Rat: 90%.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
RGS10 inhibits signal transduction by increasing the GTPASE activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. It associates specifically with the activated forms of the G protein subunits G(I)-ALPHA and G(Z)- alpha but fails to interact with the structurally and functionally distinct G(S)-alpha subunit. Activity on G(Z)-alpha is inhibited by palmitoylation of the G-protein.
Protein Aliases: Regulator of G-protein signaling 10; regulator of G-protein signalling 10; RGS10
Gene Aliases: RGS10
UniProt ID: (Human) O43665
Entrez Gene ID: (Human) 6001