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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (aa 119-137 , CEDFKKSKGPQQIHLKAKA) of RGS18 protein.|
|Storage buffer||whole serum with 50% glycerol|
|Contains||0.025% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:250-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
RGS signaling proteins are highly diverse and multifunctional proteins that act as inhibitors of G-protein signaling.RGS18, a 235 A.A protein, is the smallest member of this family. It is predominantly expressed in immune tissues and is characterized by the presence of a conserved 120A.A RGS domain. It is found to be expressed in lymphocytes, megakaryocytes and platelets and might play an important role in regulating G-protein mediated signaling in lungs and immune system. It specifically binds to GTP-bound G-alpha subunits and acts as a GAP protein, thus inhibiting G-alpha mediated signaling. It blocks MAP-Kinase activity and cAMP generation induced by G-alpha-i or G-alpha-q-coupled receptors. This protein is thought to play an important role in proliferation, differentiation and migration of megakaryocytes and platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
regulator of G-protein signalling 13; regulator of G-protein signalling 18; RP11-142L4.1