Positive Control: human RGS19-transfected 293T
Predicted Reactivity: Mouse (87%), Rat (87%), Rhesus Monkey (96%), Bovine (84%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
RGS19 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
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Protein Aliases: G alpha interacting protein; G protein signalling regulator 19; G-alpha-interacting protein; GAIP; guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G-protein signaling 19; regulator of G-protein signalling 19; RGS19; RGSGAIP
Gene Aliases: GAIP; GNAI3IP; RGS19; RGSGAIP
UniProt ID: (Human) P49795
Entrez Gene ID: (Human) 10287