Search
Invitrogen
RGS4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-95929
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RGS4 (NP_0056041)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHNSSHN KKDKVVICQR VSQEEVKKWA ESLENLISHE CGLAAFKAFL KSEYSEENID FWISCEEYKK
Positive Samples: U-251MG, HeLa, A-375, Jurkat, Raji
Target Information
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alternatively spliced; MGC2124; MGC60244; Regulator of G-protein signaling 4; RGP4; RGS4; RP11-430G6.1; schizophrenia disorder 9; unnamed protein product
Gene Aliases: AA004315; AA597169; ESTM48; ESTM50; RGP4; RGS4; SCZD9
UniProt ID: (Human) P49798, (Mouse) O08899, (Rat) P49799
Entrez Gene ID: (Human) 5999, (Mouse) 19736, (Rat) 29480
response to amphetamine
G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
negative regulation of signal transduction
positive regulation of heart rate
response to cocaine
response to ethanol
negative regulation of G-protein coupled receptor protein signaling pathway
regulation of calcium ion transport
negative regulation of dopamine receptor signaling pathway
negative regulation of cell growth involved in cardiac muscle cell development
regulation of actin filament organization
negative regulation of glycine import across plasma membrane
regulation of potassium ion transmembrane transport
negative regulation of potassium ion transmembrane transport
dorsal root ganglion development
positive regulation of excitatory postsynaptic potential
termination of G-protein coupled receptor signaling pathway
positive regulation of GTPase activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support