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Invitrogen
RHEB Polyclonal Antibody
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Product Details
PA5-20128
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from the amino terminus of human Rheb.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat heart tissue lysate.
PA5-20128 can be used with blocking peptide PEP-0246.
Target Information
Rheb encodes a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein Rheb; Ras homolog enriched in brain; Ras homolog enriched in brain 2; RAS-homolog enriched in brain; RHEB; similar to Ras homolog enriched in brain; small GTP binding protein; unnamed protein product
Gene Aliases: RHEB; Rheb1; RHEB2
UniProt ID: (Human) Q15382, (Mouse) Q921J2, (Rat) Q62639
Entrez Gene ID: (Human) 6009, (Mouse) 19744, (Rat) 26954
autophagosome assembly
cytoplasmic translation
signal transduction
small GTPase mediated signal transduction
response to virus
negative regulation of autophagy
regulation of macroautophagy
cellular response to nutrient levels
regulation of TOR signaling
positive regulation of TOR signaling
TORC1 signaling
negative regulation of translational initiation
positive regulation of translational initiation
oligodendrocyte differentiation
positive regulation of oligodendrocyte differentiation
regulation of cell cycle
negative regulation of cold-induced thermogenesis
positive regulation of TORC1 signaling
regulation of type B pancreatic cell development
metabolic process
regulation of neuronal synaptic plasticity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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