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Proteintech
RHOB Polyclonal Antibody
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Product Details
14326-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RHOB Fusion Protein Ag5593 (1-196 aa encoded by BC066954)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAIRKKLV VVGDGACGKT CLLIVFSKDE FPEVYVPTVF ENYVADIEVD GKQVELALWD TAGQEDYDRL RPLSYPDTDV ILMCFSVDSP DSLENIPEKW VPEVKHFCPN VPIILVANKK DLRSDEHVRT ELARMKQEPV RTDDGRAMAV RIQAYDYLEC SAKTKEGVRE VFETATRAAL QKRYGSQNGC INCCKVL (1-196 aa encoded by BC066954)
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aplysia RAS-related homolog 6; aplysia ras-related homolog B; ARHB; h6; oncogene RHO H6; ras homolog B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; Rho cDNA clone 6; rho protein; Rho-related GTP-binding protein RhoB; rhoB; small GTP binding protein; unnamed protein product
Gene Aliases: AA017882; ARH6; ARHB; MST081; MSTP081; RHOB; RHOH6
UniProt ID: (Human) P62745, (Rat) P62747, (Mouse) P62746
Entrez Gene ID: (Human) 388, (Rat) 64373, (Mouse) 11852
mitotic cytokinesis
angiogenesis
intracellular protein transport
apoptotic process
actin filament organization
cell adhesion
signal transduction
small GTPase mediated signal transduction
Rho protein signal transduction
endosome to lysosome transport
positive regulation of endothelial cell migration
protein transport
cell differentiation
regulation of cell migration
positive regulation of cell migration
negative regulation of cell migration
positive regulation of apoptotic process
positive regulation of angiogenesis
negative regulation of cell cycle
endothelial tube morphogenesis
cellular response to hydrogen peroxide
cellular response to ionizing radiation
regulation of modification of postsynaptic structure
obsolete transformed cell apoptotic process
cytokinesis
transport
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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