Proteintech

RHOT2 Polyclonal Antibody

RHOT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 19

RHOT2 Antibody (11237-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human colon tissue slide using (Product # 11237-1-AP) (MIRO2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

RHOT2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11237-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 5 publications 5 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RHOT2 Fusion Protein Ag1752 (319-618 aa encoded by BC014942)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DRDGALSPV ELQSLFSVFP AAPWGPELPR TVRTEAGRLP LHGYLCQWTL VTYLDVRSCL GHLGYLGYPT LCEQDQAHAI TVTREKRLDQ EKGQTQRSVL LCKVVGARGV GKSAFLQAFL GRGLGHQDTR EQPPGYAIDT VQVNGQEKYL ILCEVGTDGL LATSLDATCD VACLMFDGSD PKSFAHCASV YKHHYMDGQT PCLFVSSKAD LPEGVAVSGP SPAEFCRKHR LPAPVPFSCA GPAEPSTTIF TQLATMAAFP HLVHAELHPS SFWLRGLLGV VGAAVAAVLS FSLYRVLVKS Q (319-618 aa encoded by BC014942)

Target Information

This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission.

Journal of cell science

Coscia SM,Thompson CP,Tang Q,Baltrusaitis EE,Rhodenhiser JA,Quintero-Carmona OA,Ostap EM,Lakadamyali M,Holzbaur ELF

Wed Mar 01 00:00:00 UTC 2023

Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes.

eLife

Zhuang A,Zhuang A,Chen Y,Qin Z,Zhu D,Ren L,Wei Y,Zhou P,Yue X,He F,Xu J,Ding C

Tue May 09 00:00:00 UTC 2023

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.

Cells

Brustovetsky T,Khanna R,Brustovetsky N

Sat Apr 29 00:00:00 UTC 2023

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.

Cells

Brustovetsky T,Khanna R,Brustovetsky N

Sat Apr 29 00:00:00 UTC 2023

MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.

bioRxiv : the preprint server for biology

Kumar A,Larrea D,Pero ME,Infante P,Conenna M,Shin GJ,Grueber WB,Di Marcotullio L,Area-Gomez E,Bartolini F

Thu Mar 16 00:00:00 UTC 2023

The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.

Nature communications

Ng MYW,Charsou C,Lapao A,Singh S,Trachsel-Moncho L,Schultz SW,Nakken S,Munson MJ,Simonsen A

Fri Oct 21 00:00:00 UTC 2022

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.

Neuron

Goldsmith J,Ordureau A,Harper JW,Holzbaur ELF

Wed Mar 16 00:00:00 UTC 2022

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.

The EMBO journal

Wu Z,Berlemann LA,Bader V,Sehr DA,Dawin E,Covallero A,Meschede J,Angersbach L,Showkat C,Michaelis JB,Münch C,Rieger B,Namgaladze D,Herrera MG,Fiesel FC,Springer W,Mendes M,Stepien J,Barkovits K,Marcus K,Sickmann A,Dittmar G,Busch KB,Riedel D,Brini M,Tatzelt J,Cali T,Winklhofer KF

Thu Dec 15 00:00:00 UTC 2022

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.

EMBO reports

Wang F,Chen X,Cheng H,Song L,Liu J,Caplan S,Zhu L,Wu JY

Mon Jul 05 00:00:00 UTC 2021

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.

EMBO reports

Wang F,Chen X,Cheng H,Song L,Liu J,Caplan S,Zhu L,Wu JY

Mon Jul 05 00:00:00 UTC 2021

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.

EMBO reports

Wang F,Chen X,Cheng H,Song L,Liu J,Caplan S,Zhu L,Wu JY

Mon Jul 05 00:00:00 UTC 2021

CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.

Cells

Brustovetsky T,Khanna R,Brustovetsky N

Sun Oct 17 00:00:00 UTC 2021

CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.

Cells

Brustovetsky T,Khanna R,Brustovetsky N

Sun Oct 17 00:00:00 UTC 2021

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.

Nature cell biology

König T,Nolte H,Aaltonen MJ,Tatsuta T,Krols M,Stroh T,Langer T,McBride HM

Wed Dec 01 00:00:00 UTC 2021

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.

Nature cell biology

König T,Nolte H,Aaltonen MJ,Tatsuta T,Krols M,Stroh T,Langer T,McBride HM

Wed Dec 01 00:00:00 UTC 2021

miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission.

Molecular therapy. Nucleic acids

Woo HN,Park S,Kim HL,Jung MK,Pack CG,Park J,Cho Y,Jo DG,Kim DK,Mook-Jung I,Kim SW,Lee H

Fri Mar 05 00:00:00 UTC 2021

miR-351-5p/Miro2 axis contributes to hippocampal neural progenitor cell death via unbalanced mitochondrial fission.

Molecular therapy. Nucleic acids

Woo HN,Park S,Kim HL,Jung MK,Pack CG,Park J,Cho Y,Jo DG,Kim DK,Mook-Jung I,Kim SW,Lee H

Fri Mar 05 00:00:00 UTC 2021

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.

Science advances

Antico O,Ordureau A,Stevens M,Singh F,Nirujogi RS,Gierlinski M,Barini E,Rickwood ML,Prescott A,Toth R,Ganley IG,Harper JW,Muqit MMK

Fri Nov 12 00:00:00 UTC 2021

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.

Cells

Brustovetsky T,Khanna R,Brustovetsky N

Mon Nov 15 00:00:00 UTC 2021

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.

Cells

Brustovetsky T,Khanna R,Brustovetsky N

Mon Nov 15 00:00:00 UTC 2021

A dual druggable genome-wide siRNA and compound library screening approach identifies modulators of parkin recruitment to mitochondria.

The Journal of biological chemistry

Scott HL,Buckner N,Fernandez-Albert F,Pedone E,Postiglione L,Shi G,Allen N,Wong LF,Magini L,Marucci L,O'Sullivan GA,Cole S,Powell J,Maycox P,Uney JB

Fri Mar 06 00:00:00 UTC 2020

Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.

Biochemical pharmacology

Gao Y,Li J,Li J,Hu C,Zhang L,Yan J,Li L,Zhang L

Wed Jul 01 00:00:00 UTC 2020

Miro proteins prime mitochondria for Parkin translocation and mitophagy.

The EMBO journal

Safiulina D,Kuum M,Choubey V,Gogichaishvili N,Liiv J,Hickey MA,Cagalinec M,Mandel M,Zeb A,Liiv M,Kaasik A

Tue Jan 15 00:00:00 UTC 2019

Miro proteins prime mitochondria for Parkin translocation and mitophagy.

The EMBO journal

Safiulina D,Kuum M,Choubey V,Gogichaishvili N,Liiv J,Hickey MA,Cagalinec M,Mandel M,Zeb A,Liiv M,Kaasik A

Tue Jan 15 00:00:00 UTC 2019

Miro proteins prime mitochondria for Parkin translocation and mitophagy.

The EMBO journal

Safiulina D,Kuum M,Choubey V,Gogichaishvili N,Liiv J,Hickey MA,Cagalinec M,Mandel M,Zeb A,Liiv M,Kaasik A

Tue Jan 15 00:00:00 UTC 2019

Miro proteins prime mitochondria for Parkin translocation and mitophagy.

The EMBO journal

Safiulina D,Kuum M,Choubey V,Gogichaishvili N,Liiv J,Hickey MA,Cagalinec M,Mandel M,Zeb A,Liiv M,Kaasik A

Tue Jan 15 00:00:00 UTC 2019

Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.

EMBO reports

Koyano F,Yamano K,Kosako H,Kimura Y,Kimura M,Fujiki Y,Tanaka K,Matsuda N

Thu Dec 05 00:00:00 UTC 2019

Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.

Protein & cell

Lee CA,Chin LS,Li L

Wed Aug 01 00:00:00 UTC 2018

Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.

Protein & cell

Lee CA,Chin LS,Li L

Wed Aug 01 00:00:00 UTC 2018

Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.

Protein & cell

Lee CA,Chin LS,Li L

Wed Aug 01 00:00:00 UTC 2018

Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.

Protein & cell

Lee CA,Chin LS,Li L

Wed Aug 01 00:00:00 UTC 2018

Principles of the mitochondrial fusion and fission cycle in neurons.

Journal of cell science

Cagalinec M,Safiulina D,Liiv M,Liiv J,Choubey V,Wareski P,Veksler V,Kaasik A

Wed May 15 00:00:00 UTC 2013

Principles of the mitochondrial fusion and fission cycle in neurons.

Journal of cell science

Cagalinec M,Safiulina D,Liiv M,Liiv J,Choubey V,Wareski P,Veksler V,Kaasik A

Wed May 15 00:00:00 UTC 2013

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.

Biochemistry

Weihofen A,Thomas KJ,Ostaszewski BL,Cookson MR,Selkoe DJ

Tue Mar 10 00:00:00 UTC 2009

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.

Biochemistry

Weihofen A,Thomas KJ,Ostaszewski BL,Cookson MR,Selkoe DJ

Tue Mar 10 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: MIRO-2; mitochondrial Rho (MIRO) GTPase 2; mitochondrial Rho 2; Mitochondrial Rho GTPase 2; Ras homolog gene family member T2; ras homolog gene family, member T2

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Gene Aliases: ARHT2; C16orf39; MIRO-2; MIRO2; RASL; RHOT2

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UniProt ID: (Human) Q8IXI1, (Mouse) Q8JZN7

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Entrez Gene ID: (Human) 89941, (Mouse) 214952

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Function(s)

GTPase activity calcium ion binding protein binding GTP binding nucleotide binding hydrolase activity metal ion binding small GTPase

Process(es)

small GTPase mediated signal transduction cellular homeostasis mitochondrion transport along microtubule regulation of small GTPase mediated signal transduction mitochondrial outer membrane permeabilization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RHOT2 Polyclonal Antibody

RHOT2 Antibody (11237-1-AP) in IHC (P)

Product Details

11237-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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