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Proteintech
RIM1 Polyclonal Antibody
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Product Details
24576-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RIM1 Fusion Protein Ag20161 (923-1039 aa encoded by BC152435)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KSTTLTVPE QQRTTHHRSR SVSPHRGNDQ GKPRSRLPNV PLQRSLDEIH PTRRSRSPTR HHDASRSPVD HRTRDVDSQY LSEQDSELLM LPRAKRGRSA ECLHTTR (923-1039 aa encoded by BC152435)
Target Information
Rims1 is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. Rims1 also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations in the Rims1 gene have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Further, Rims1 may act as scaffold protein that regulates neurotransmitter release at the active zone. Rims1 may also be essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Rims1 also plays a role in dendrite formation by melanocytes. Multiple transcript variants encoding different isoforms have been described for this Rims1. Diseases associated with RIMS1 include Cone-Rod Dystrophy 7 and Retinitis Pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Rab-3-interacting molecule 1; Rab-3-interacting protein 1; Rab-3-interacting protein 2; Rab3 effector; Rab3 interacting protein 1; rab3-interacting molecule 1; rab3-interacting protein 1; RAB3-interacting protein 2; regulating synaptic membrane exocytosis 1 beta; Regulating synaptic membrane exocytosis protein 1; RIM 1; Rim1b protein; synaptic exocytosis regulator 1
Gene Aliases: C030033M19Rik; CORD7; KIAA0340; mKIAA0340; Nbla00761; Rab3ip1; RAB3IP2; RIM; RIM1; RIM1a; RIM1alpha; RIMS1; Serg1
UniProt ID: (Human) Q86UR5, (Mouse) Q99NE5, (Rat) Q9JIR4
Entrez Gene ID: (Human) 22999, (Mouse) 116837, (Rat) 84556
protein complex assembly
intracellular protein transport
neurotransmitter secretion
visual perception
positive regulation of gene expression
glutamate secretion
synaptic vesicle exocytosis
calcium ion regulated exocytosis
regulated exocytosis
secretion
regulation of neurotransmitter secretion
regulation of catalytic activity
response to stimulus
long-term synaptic potentiation
membrane fusion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
positive regulation of excitatory postsynaptic potential
transport
neurotransmitter transport
exocytosis
positive regulation of synaptic vesicle priming
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
calcium ion-regulated exocytosis of neurotransmitter
spontaneous neurotransmitter secretion
regulation of synaptic vesicle exocytosis
positive regulation of synaptic vesicle fusion to presynaptic membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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